John J. OShea
John J. OShea
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Cited by
Cited by
Jaks and STATs: biological implications
WJ Leonard, JJ O'Shea
Annual review of immunology 16 (1), 293-322, 1998
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
A Laurence, CM Tato, TS Davidson, Y Kanno, Z Chen, Z Yao, RB Blank, ...
Immunity 26 (3), 371-381, 2007
Generation of pathogenic TH17 cells in the absence of TGF-β signalling
K Ghoreschi, A Laurence, XP Yang, CM Tato, MJ McGeachy, JE Konkel, ...
Nature 467 (7318), 967-971, 2010
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells
JJ O’Shea, WE Paul
Science 327 (5969), 1098-1102, 2010
Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes
MF McDermott, I Aksentijevich, J Galon, EM McDermott, BW Ogunkolade, ...
Cell 97 (1), 133-144, 1999
Cytokine signaling in 2002: new surprises in the Jak/Stat pathway
JJ O'Shea, M Gadina, RD Schreiber
Cell 109 (2), S121-S131, 2002
The JAK-STAT pathway: impact on human disease and therapeutic intervention
JJ O'Shea, DM Schwartz, AV Villarino, M Gadina, IB McInnes, A Laurence
Annual review of medicine 66, 311-328, 2015
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
JD Milner, JM Brenchley, A Laurence, AF Freeman, BJ Hill, KM Elias, ...
Nature 452 (7188), 773-776, 2008
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
G Wei, L Wei, J Zhu, C Zang, J Hu-Li, Z Yao, K Cui, Y Kanno, TY Roh, ...
Immunity 30 (1), 155-167, 2009
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo
MJ McGeachy, Y Chen, CM Tato, A Laurence, B Joyce-Shaikh, ...
Nature immunology 10 (3), 314-324, 2009
Janus kinases in immune cell signaling
K Ghoreschi, A Laurence, JJ O’Shea
Immunological reviews 228 (1), 273-287, 2009
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward, M Gadina, JJ O'Shea
Nature reviews Drug discovery 16 (12), 843-862, 2017
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
JS Stumhofer, A Laurence, EH Wilson, E Huang, CM Tato, LM Johnson, ...
Nature immunology 7 (9), 937-945, 2006
JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
JJ O'Shea, R Plenge
Immunity 36 (4), 542-550, 2012
T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells
AA Lighvani, DM Frucht, D Jankovic, H Yamane, J Aliberti, BD Hissong, ...
Proceedings of the National Academy of Sciences 98 (26), 15137-15142, 2001
Mechanisms and consequences of Jak–STAT signaling in the immune system
AV Villarino, Y Kanno, JJ O'Shea
Nature immunology 18 (4), 374-384, 2017
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10
JS Stumhofer, JS Silver, A Laurence, PM Porrett, TH Harris, LA Turka, ...
Nature immunology 8 (12), 1363-1371, 2007
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development
SM Russell, N Tayebi, H Nakajima, MC Riedy, JL Roberts, MJ Aman, ...
Science 270 (5237), 797-800, 1995
Cytokine signaling modules in inflammatory responses
JJ O'Shea, PJ Murray
Immunity 28 (4), 477-487, 2008
JAKs and STATs in immunity, immunodeficiency, and cancer
JJ O'Shea, SM Holland, LM Staudt
New England Journal of Medicine 368 (2), 161-170, 2013
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