| A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology. C Zhao, AC Mirando, RJ Sové, TX Medeiros, BH Annex, AS Popel PLoS computational biology 15 (11), e1007468, 2019 | 40 | 2019 |
| Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions C Zhao, JS Isenberg, AS Popel Journal of cellular and molecular medicine 22 (4), 2086-2097, 2018 | 39 | 2018 |
| Computational model of microRNA control of HIF-VEGF pathway: insights into the pathophysiology of ischemic vascular disease and cancer C Zhao, AS Popel PLoS computational biology 11 (11), e1004612, 2015 | 39 | 2015 |
| QSP‐IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno‐Oncology Applications RJ Sové, M Jafarnejad, C Zhao, H Wang, H Ma, AS Popel CPT: Pharmacometrics & Systems Pharmacology 9 (9), 484-497, 2020 | 35 | 2020 |
| A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization C Zhao, TX Medeiros, RJ Sové, BH Annex, AS Popel iScience, 2021 | 28 | 2021 |
| Mechanistic Computational Models of MicroRNA-Mediated Signaling Networks in Human Diseases C Zhao, Y Zhang, AS Popel International journal of molecular sciences 20 (2), 421, 2019 | 25 | 2019 |
| Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier‐Free Nanoassembly of Fluorinated Prodrug and siRNA P Wu, H Zhang, M Sun, S Mao, Q He, Y Shi, Y Deng, Z Dong, Q Xu, ... Advanced Materials 34 (38), 2203019, 2022 | 24 | 2022 |
| Systems biology of angiogenesis signaling: Computational models and omics Y Zhang, H Wang, RHM Oliveira, C Zhao, AS Popel WIREs Mechanisms of Disease, e1550, 2021 | 23 | 2021 |
| Transcriptional and post-transcriptional regulation of thrombospondin-1 expression: a computational model C Zhao, JS Isenberg, AS Popel PLoS computational biology 13 (1), e1005272, 2017 | 20 | 2017 |
| Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer H Wang, C Zhao, CA Santa-Maria, LA Emens, AS Popel iScience 25 (8), 2022 | 18 | 2022 |
| Dynamic Multiscale Regulation of Perfusion Recovery in Experimental Peripheral Arterial Disease: A Mechanistic Computational Model C Zhao, JL Heuslein, Y Zhang, BH Annex, AS Popel JACC: Basic to Translational Science, 2022 | 7 | 2022 |
| Protocol for simulating macrophage signal transduction and phenotype polarization using a large-scale mechanistic computational model C Zhao, A Popel STAR Protocols 2 (3), 100739, 2021 | 2 | 2021 |
| Signaling-biophysical modeling unravels mechanistic control of red blood cell phagocytosis by macrophages in sickle cell disease Y Zhang, Y Qiang, H Li, G Li, L Lu, M Dao, GE Karniadakis, AS Popel, ... PNAS Nexus, pgae031, 2024 | 1 | 2024 |
| Temporal colonization and metabolic regulation of the gut microbiome in neonatal oxen at single nucleotide resolution Q Dong, D Hua, X Wang, Y Jiao, L Liu, Q Deng, T Wu, H Zou, C Zhao, ... The ISME Journal 18 (1), wrad022, 2024 | 1 | 2024 |
| Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases Y Zhang, C Zhao, AS Popel The Vasculome From Many, One, 2022 | 1 | 2022 |
| Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities Y Zhou, J Chu, S Zhao, G Li, Z Fu, S Zhang, X Gao, W Ma, K Shen, Y Gao, ... Acta Pharmacologica Sinica, 1-18, 2024 | | 2024 |
| Multiphysics and multiscale modeling of erythrophagocytosis H Li, Y Zhang, C Zhao, M Dao, A Popel, G Karniadakis Bulletin of the American Physical Society 68, 2023 | | 2023 |
| A Translational Multiscale Quantitative Systems Pharmacology Model of CAR-T Cell Therapy in Solid Tumors S Yang, W Wang, D Xu, C Zhao ISQP 2023, 2023 | | 2023 |
| 新药研发中的定量系统药理学(QSP)模型与虚拟临床试验: 发展及前沿应用 C Zhao, G Li, Y Wang Acta Pharmaceutica Sinica (药学学报) 58 (11), 3296-3310, 2023 | | 2023 |
| Virtual Patients and Digital Twins in the Systems Analysis of Drug Discovery and Development C Zhao, H He, H Ma Frontiers in Systems Biology 3, 1293076, 2023 | | 2023 |
Aleksander S. PopelProfessor of Biomedical Engineering, Johns Hopkins University, School of MedicineVerified email at jhu.edu
