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Ian Sipula
Ian Sipula
Other namesIan J Sipula
Senior Research Laboratory Manager
Verified email at pitt.edu
Title
Cited by
Cited by
Year
Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance
W Huang, A Metlakunta, N Dedousis, P Zhang, I Sipula, JJ Dube, ...
diabetes 59 (2), 347-357, 2010
6002010
Dendritic Cells Promote Macrophage Infiltration and Comprise a Substantial Proportion of Obesity-Associated Increases in CD11c+ Cells in Adipose Tissue and Liver
M Stefanovic-Racic, X Yang, MS Turner, BS Mantell, DB Stolz, ...
Diabetes 61 (9), 2330-2339, 2012
2432012
A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels
M Stefanovic-Racic, G Perdomo, BS Mantell, IJ Sipula, NF Brown, ...
American Journal of Physiology-Endocrinology and Metabolism 294 (5), E969-E977, 2008
2302008
The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes
NF Brown, M Stefanovic-Racic, IJ Sipula, G Perdomo
Metabolism 56 (11), 1500-1507, 2007
1822007
Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic …
JC Lopez-Talavera, A Garcia-Ocaña, I Sipula, KK Takane, ...
Endocrinology 145 (2), 467-474, 2004
1542004
Rapamycin-mediated inhibition of mammalian target of rapamycin in skeletal muscle cells reduces glucose utilization and increases fatty acid oxidation
IJ Sipula, NF Brown, G Perdomo
Metabolism 55 (12), 1637-1644, 2006
1342006
Mice Lacking NKT Cells but with a Complete Complement of CD8+ T-Cells Are Not Protected against the Metabolic Abnormalities of Diet-Induced Obesity
BS Mantell, M Stefanovic-Racic, X Yang, N Dedousis, IJ Sipula, ...
PloS one 6 (6), e19831, 2011
1242011
Tregs facilitate obesity and insulin resistance via a Blimp-1/IL-10 axis
LY Beppu, RGR Mooli, X Qu, GJ Marrero, CA Finley, AN Fooks, ZP Mullen, ...
JCI insight 6 (3), 2021
732021
Cholesterol sulfate and cholesterol sulfotransferase inhibit gluconeogenesis by targeting hepatocyte nuclear factor 4α
X Shi, Q Cheng, L Xu, J Yan, M Jiang, J He, M Xu, M Stefanovic-Racic, ...
Molecular and cellular biology, 2014
492014
Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice
DV Chartoumpekis, DL Palliyaguru, N Wakabayashi, M Fazzari, ...
American Journal of Physiology-Endocrinology and Metabolism 315 (2), E180-E195, 2018
462018
Abnormal lipid processing but normal long-term repopulation potential of myc−/− hepatocytes
LR Edmunds, PA Otero, L Sharma, S D'souza, JM Dolezal, S David, J Lu, ...
Oncotarget 7 (21), 30379, 2016
372016
Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice
DV Chartoumpekis, Y Yagishita, M Fazzari, DL Palliyaguru, UNM Rao, ...
JCI insight 3 (5), 2018
322018
DNA methylation alters transcriptional rates of differentially expressed genes and contributes to pathophysiology in mice fed a high fat diet
P Zhang, T Chu, N Dedousis, BS Mantell, I Sipula, L Li, KD Bunce, ...
Molecular Metabolism 6 (4), 327-339, 2017
322017
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance
LR Edmunds, B Xie, AM Mills, BR Huckestein, R Undamatla, A Murali, ...
Molecular Metabolism 41, 101051, 2020
312020
Kupffer cells facilitate the acute effects of leptin on hepatic lipid metabolism
A Metlakunta, W Huang, M Stefanovic-Racic, N Dedousis, I Sipula, ...
American Journal of Physiology-Endocrinology and Metabolism 312 (1), E11-E18, 2017
312017
Hepatocyte-specific ablation or whole-body inhibition of xanthine oxidoreductase in mice corrects obesity-induced systemic hyperuricemia without improving metabolic abnormalities
DB Harmon, WK Mandler, IJ Sipula, N Dedousis, SE Lewis, JT Eckels, ...
Diabetes 68 (6), 1221-1229, 2019
302019
Similar degrees of obesity induced by diet or aging cause strikingly different immunologic and metabolic outcomes
KB Krishna, M Stefanovic‐Racic, N Dedousis, I Sipula, RM O'Doherty
Physiological reports 4 (6), e12708, 2016
242016
Mitochondrial energetics in skeletal muscle are associated with leg power and cardiorespiratory fitness in the study of muscle, mobility and aging
T Mau, LY Lui, G Distefano, PA Kramer, SV Ramos, FGS Toledo, ...
The Journals of Gerontology: Series A 78 (8), 1367-1375, 2023
212023
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply
DB Harmon, C Wu, N Dedousis, IJ Sipula, M Stefanovic-Racic, ...
American Journal of Physiology-Endocrinology and Metabolism 315 (5), E758-E770, 2018
172018
Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis
R Undamatla, OG Fagunloye, J Chen, LR Edmunds, A Murali, A Mills, ...
Scientific Reports 13 (1), 7575, 2023
132023
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