| Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... cell 163 (3), 759-771, 2015 | 4928 | 2015 |
| Nucleic acid detection with CRISPR-Cas13a/C2c2 JS Gootenberg, OO Abudayyeh, JW Lee, P Essletzbichler, AJ Dy, J Joung, ... Science 356 (6336), 438-442, 2017 | 3040 | 2017 |
| Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex S Konermann, MD Brigham, AE Trevino, J Joung, OO Abudayyeh, ... Nature 517 (7536), 583-588, 2015 | 3028 | 2015 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2263 | 2016 |
| Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6 JS Gootenberg, OO Abudayyeh, MJ Kellner, J Joung, JJ Collins, F Zhang Science 360 (6387), 439-444, 2018 | 2126 | 2018 |
| RNA targeting with CRISPR–Cas13 OO Abudayyeh, JS Gootenberg, P Essletzbichler, S Han, J Joung, ... Nature 550 (7675), 280-284, 2017 | 1921 | 2017 |
| RNA editing with CRISPR-Cas13 DBT Cox, JS Gootenberg, OO Abudayyeh, B Franklin, MJ Kellner, J Joung, ... Science 358 (6366), 1019-1027, 2017 | 1834 | 2017 |
| Discovery and functional characterization of diverse class 2 CRISPR-Cas systems S Shmakov, OO Abudayyeh, KS Makarova, YI Wolf, JS Gootenberg, ... Molecular cell 60 (3), 385-397, 2015 | 1421 | 2015 |
| Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways WS Chung, LE Clarke, GX Wang, BK Stafford, A Sher, C Chakraborty, ... Nature 504 (7480), 394-400, 2013 | 1293 | 2013 |
| Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening J Joung, S Konermann, JS Gootenberg, OO Abudayyeh, RJ Platt, ... Nature protocols 12 (4), 828-863, 2017 | 1183 | 2017 |
| Detection of SARS-CoV-2 with SHERLOCK one-pot testing J Joung, A Ladha, M Saito, NG Kim, AE Woolley, M Segel, RPJ Barretto, ... New England Journal of Medicine 383 (15), 1492-1494, 2020 | 664 | 2020 |
| Clinical validation of a Cas13-based assay for the detection of SARS-CoV-2 RNA M Patchsung, K Jantarug, A Pattama, K Aphicho, S Suraritdechachai, ... Nature biomedical engineering 4 (12), 1140-1149, 2020 | 537 | 2020 |
| A cytosine deaminase for programmable single-base RNA editing OO Abudayyeh, JS Gootenberg, B Franklin, J Koob, MJ Kellner, A Ladha, ... Science 365 (6451), 382-386, 2019 | 416 | 2019 |
| Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood J Joung, JM Engreitz, S Konermann, OO Abudayyeh, VK Verdine, F Aguet, ... Nature 548 (7667), 343-346, 2017 | 414 | 2017 |
| High-resolution interrogation of functional elements in the noncoding genome NE Sanjana, J Wright, K Zheng, O Shalem, P Fontanillas, J Joung, ... Science 353 (6307), 1545-1549, 2016 | 321 | 2016 |
| Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease JE Dahlman, OO Abudayyeh, J Joung, JS Gootenberg, F Zhang, ... Nature biotechnology 33 (11), 1159-1161, 2015 | 308 | 2015 |
| Point-of-care testing for COVID-19 using SHERLOCK diagnostics J Joung, A Ladha, M Saito, M Segel, R Bruneau, WH Mee-li, NG Kim, ... MedRxiv, 2020 | 303 | 2020 |
| Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes WS Chung, PB Verghese, C Chakraborty, J Joung, BT Hyman, JD Ulrich, ... Proceedings of the National Academy of Sciences 113 (36), 10186-10191, 2016 | 233 | 2016 |
| CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours RC Larson, MC Kann, SR Bailey, NJ Haradhvala, PM Llopis, AA Bouffard, ... Nature 604 (7906), 563-570, 2022 | 230 | 2022 |
| A transcription factor atlas of directed differentiation J Joung, S Ma, T Tay, KR Geiger-Schuller, PC Kirchgatterer, VK Verdine, ... Cell 186 (1), 209-229. e26, 2023 | 91 | 2023 |
Jonathan S. GootenbergMcGovern Fellow, MITVerified email at mit.edu
