Phospholipase A2—a structural review RK Arni, RJ Ward Toxicon 34 (8), 827-841, 1996 | 533 | 1996 |
Structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom RK Arni, RJ Ward, JM Gutiérrez, A Tulinsky Acta Crystallographica Section D: Biological Crystallography 51 (3), 311-317, 1995 | 149 | 1995 |
Structural basis for glucose tolerance in GH1 β-glucosidases PO de Giuseppe, TACB Souza, FHM Souza, LM Zanphorlin, CB Machado, ... Acta Crystallographica Section D: Biological Crystallography 70 (6), 1631-1639, 2014 | 143 | 2014 |
Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis RJ Ward, L Chioato, AHC de OLIVEIRA, R Ruller, JM Sá Biochemical Journal 362 (1), 89-96, 2002 | 134 | 2002 |
Dissociation of enzymatic and pharmacological properties of piratoxins-I and-III, two myotoxic phospholipases A2 from Bothrops pirajai snake venom AM Soares, SH Andrião-Escarso, RK Bortoleto, L Rodrigues-Simioni, ... Archives of Biochemistry and Biophysics 387 (2), 188-196, 2001 | 126 | 2001 |
Glucose tolerant and glucose stimulated β-glucosidases–a review JCS Salgado, LP Meleiro, S Carli, RJ Ward Bioresource technology 267, 704-713, 2018 | 117 | 2018 |
Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in bothropstoxin I, a dimeric Lys49‐phospholipase A2 homologue MT da Silva Giotto, RC Garratt, G Oliva, YP Mascarenhas, JR Giglio, ... Proteins: Structure, Function, and Bioinformatics 30 (4), 442-454, 1998 | 117 | 1998 |
Crystallographic and spectroscopic characterization of a molecular hinge: Conformational changes in bothropstoxin I, a dimeric Lys49‐phospholipase A2 homologue MT da Silva Giotto, RC Garratt, G Oliva, YP Mascarenhas, JR Giglio, ... Proteins: Structure, Function, and Bioinformatics 30 (4), 442-454, 1998 | 117 | 1998 |
Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis L Chioato, RJ Ward Toxicon 42 (8), 869-883, 2003 | 112 | 2003 |
Isolation, purification, and physicochemical characterization of a D-galactose-binding lectin from seeds of Erythrina speciosa EHE Konozy, ES Bernardes, C Rosa, V Faca, LJ Greene, RJ Ward Archives of Biochemistry and Biophysics 410 (2), 222-229, 2003 | 105 | 2003 |
Dissecting structure–function–stability relationships of a thermostable GH5-CBM3 cellulase from Bacillus subtilis 168 CR Santos, JH Paiva, ML Sforca, JL Neves, RZ Navarro, J Cota, PK Akao, ... Biochemical Journal 441 (1), 95-104, 2012 | 103 | 2012 |
Thermostable variants of the recombinant xylanase a from Bacillus subtilis produced by directed evolution show reduced heat capacity changes R Ruller, L Deliberto, TL Ferreira, RJ Ward Proteins: Structure, Function, and Bioinformatics 70 (4), 1280-1293, 2008 | 92 | 2008 |
Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2 L Chioato, AHC OLIVEIRA, R Ruller, JM Sá, RJ Ward Biochemical journal 366 (3), 971-976, 2002 | 92 | 2002 |
A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change ALB Ambrosio, MC Nonato, HSS de Araújo, R Arni, RJ Ward, CL Ownby, ... Journal of Biological Chemistry 280 (8), 7326-7335, 2005 | 88 | 2005 |
Histidine residues near the N terminus of staphylococcal alpha-toxin as reporters of regions that are critical for oligomerization and pore formation R Jursch, A Hildebrand, G Hobom, J Tranum-Jensen, R Ward, M Kehoe, ... Infection and immunity 62 (6), 2249-2256, 1994 | 88 | 1994 |
Engineering the pattern of protein glycosylation modulates the thermostability of a GH11 xylanase R Fonseca-Maldonado, DS Vieira, JS Alponti, E Bonneil, P Thibault, ... Journal of biological chemistry 288 (35), 25522-25534, 2013 | 87 | 2013 |
Structural and functional analysis of BmjMIP, a phospholipase A2 myotoxin inhibitor protein from Bothrops moojeni snake plasma AM Soares, S Marcussi, RG Stábeli, SC França, JR Giglio, RJ Ward, ... Biochemical and biophysical research communications 302 (2), 193-200, 2003 | 87 | 2003 |
Synthetic biology approaches to improve biocatalyst identification in metagenomic library screening ME Guazzaroni, R Silva‐Rocha, RJ Ward Microbial Biotechnology 8 (1), 52-64, 2015 | 81 | 2015 |
Biochemical and structural characterization of a β-1, 3–1, 4-glucanase from Bacillus subtilis 168 GP Furtado, LF Ribeiro, CR Santos, CC Tonoli, AR De Souza, RR Oliveira, ... Process Biochemistry 46 (5), 1202-1206, 2011 | 80 | 2011 |
Mapping of the structural determinants of artificial and biological membrane damaging activities of a Lys49 phospholipase A2 by scanning alanine mutagenesis L Chioato, EA Aragão, TL Ferreira, AI de Medeiros, LH Faccioli, RJ Ward Biochimica et Biophysica Acta (BBA)-Biomembranes 1768 (5), 1247-1257, 2007 | 79 | 2007 |