Jaime M. Reyes
Jaime M. Reyes
Novartis Institutes for BioMedical Research
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BET bromodomain proteins function as master transcription elongation factors independent of CDK9 recruitment
GE Winter, A Mayer, DL Buckley, MA Erb, JE Roderick, S Vittori, JM Reyes, ...
Molecular cell 67 (1), 5-18. e19, 2017
Dual targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms
M Kleppe, R Koche, L Zou, P van Galen, CE Hill, L Dong, S De Groote, ...
Cancer cell 33 (1), 29-43. e7, 2018
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
LN Gechijian, DL Buckley, MA Lawlor, JM Reyes, J Paulk, CJ Ott, ...
Nature chemical biology 14 (4), 405-412, 2018
Loss of Dnmt3a immortalizes hematopoietic stem cells in vivo
M Jeong, HJ Park, H Celik, EL Ostrander, JM Reyes, A Guzman, ...
Cell reports 23 (1), 1-10, 2018
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
R Zeid, MA Lawlor, E Poon, JM Reyes, M Fulciniti, MA Lopez, TG Scott, ...
Nature genetics 50 (4), 515-523, 2018
Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis
AD Viny, CJ Ott, B Spitzer, M Rivas, C Meydan, E Papalexi, D Yelin, ...
Journal of Experimental Medicine 212 (11), 1819-1832, 2015
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
DP Labbé, G Zadra, M Yang, JM Reyes, CY Lin, S Cacciatore, EM Ebot, ...
Nature communications 10 (1), 4358, 2019
Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer
S Shu, HJ Wu, YG Jennifer, R Zeid, IS Harris, B Jovanović, K Murphy, ...
Molecular cell 78 (6), 1096-1113. e8, 2020
Oncogenic deregulation of EZH2 as an opportunity for targeted therapy in lung cancer
H Zhang, J Qi, JM Reyes, L Li, PK Rao, F Li, CY Lin, JA Perry, MA Lawlor, ...
Cancer discovery 6 (9), 1006-1021, 2016
PI3K/AKT signaling regulates H3K4 methylation in breast cancer
JM Spangle, KM Dreijerink, AC Groner, H Cheng, CE Ohlson, J Reyes, ...
Cell reports 15 (12), 2692-2704, 2016
BET bromodomain proteins regulate enhancer function during adipogenesis
JD Brown, ZB Feldman, SP Doherty, JM Reyes, PB Rahl, CY Lin, ...
Proceedings of the National Academy of Sciences 115 (9), 2144-2149, 2018
Enhancer-mediated oncogenic function of the menin tumor suppressor in breast cancer
KMA Dreijerink, AC Groner, ESM Vos, A Font-Tello, L Gu, D Chi, J Reyes, ...
Cell reports 18 (10), 2359-2372, 2017
Large DNA methylation nadirs anchor chromatin loops maintaining hematopoietic stem cell identity
X Zhang, M Jeong, X Huang, XQ Wang, X Wang, W Zhou, MS Shamim, ...
Molecular cell 78 (3), 506-521. e6, 2020
Trisomy of a Down syndrome critical region globally amplifies transcription via HMGN1 overexpression
CT Mowery, JM Reyes, L Cabal-Hierro, KJ Higby, KL Karlin, JH Wang, ...
Cell reports 25 (7), 1898-1911. e5, 2018
Deregulation of the Ras-Erk signaling axis modulates the enhancer landscape
B Nabet, PÓ Broin, JM Reyes, K Shieh, CY Lin, CM Will, R Popovic, ...
Cell reports 12 (8), 1300-1313, 2015
Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain
MT Buckley, ED Sun, BM George, L Liu, N Schaum, L Xu, JM Reyes, ...
Nature Aging 3 (1), 121-137, 2023
Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor
YH Huang, CW Chen, V Sundaramurthy, M Słabicki, D Hao, CJ Watson, ...
Cancer discovery 12 (1), 220-235, 2022
Tissue-biased expansion of DNMT3A-mutant clones in a mosaic individual is associated with conserved epigenetic erosion
A Tovy, JM Reyes, MC Gundry, L Brunetti, H Lee-Six, M Petljak, HJ Park, ...
Cell Stem Cell 27 (2), 326-335. e4, 2020
Exercise reprograms the inflammatory landscape of multiple stem cell compartments during mammalian aging
L Liu, S Kim, MT Buckley, JM Reyes, J Kang, L Tian, M Wang, A Lieu, ...
Cell stem cell 30 (5), 689-705. e4, 2023
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome
A Tovy, C Rosas, AS Gaikwad, G Medrano, L Zhang, JM Reyes, ...
Haematologica, 2021
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