Jonathan Stokes
Jonathan Stokes
Assistant Professor, Biochemistry & Biomedical Sciences, McMaster University
Verified email at - Homepage
Cited by
Cited by
A deep learning approach to antibiotic discovery
JM Stokes, K Yang, K Swanson, W Jin, A Cubillos-Ruiz, NM Donghia, ...
Cell 180 (4), 688-702. e13, 2020
Bacterial metabolism and antibiotic efficacy
JM Stokes, AJ Lopatkin, MA Lobritz, JJ Collins
Cell metabolism 30 (2), 251-259, 2019
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Nature microbiology 2 (5), 1-8, 2017
Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics
CR MacNair, JM Stokes, LA Carfrae, AA Fiebig-Comyn, BK Coombes, ...
Nature communications 9 (1), 458, 2018
Clinically relevant mutations in core metabolic genes confer antibiotic resistance
AJ Lopatkin, SC Bening, AL Manson, JM Stokes, MA Kohanski, ...
Science 371 (6531), eaba0862, 2021
Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate
AJ Lopatkin, JM Stokes, EJ Zheng, JH Yang, MK Takahashi, L You, ...
Nature microbiology 4 (12), 2109-2117, 2019
Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force
MA Farha, S French, JM Stokes, ED Brown
ACS infectious diseases 4 (3), 382-390, 2017
Deep learning identifies synergistic drug combinations for treating COVID-19
W Jin, JM Stokes, RT Eastman, Z Itkin, AV Zakharov, JJ Collins, ...
Proceedings of the National Academy of Sciences 118 (39), e2105070118, 2021
Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii
G Liu, DB Catacutan, K Rathod, K Swanson, W Jin, JC Mohammed, ...
Nature Chemical Biology 19 (11), 1342-1350, 2023
Cold stress makes Escherichia coli susceptible to glycopeptide antibiotics by altering outer membrane integrity
JM Stokes, S French, OG Ovchinnikova, C Bouwman, C Whitfield, ...
Cell chemical biology 23 (2), 267-277, 2016
Discovery of a small molecule that inhibits bacterial ribosome biogenesis
JM Stokes, JH Davis, CS Mangat, JR Williamson, ED Brown
Elife 3, e03574, 2014
Eradicating bacterial persisters with combinations of strongly and weakly metabolism-dependent antibiotics
EJ Zheng, JM Stokes, JJ Collins
Cell chemical biology 27 (12), 1544-1552. e3, 2020
Cytoplasmic condensation induced by membrane damage is associated with antibiotic lethality
F Wong, JM Stokes, B Cervantes, S Penkov, J Friedrichs, LD Renner, ...
Nature communications 12 (1), 2321, 2021
A multiplexable assay for screening antibiotic lethality against drug-tolerant bacteria
JM Stokes, A Gutierrez, AJ Lopatkin, IW Andrews, S French, I Matic, ...
Nature Methods 16 (4), 303-306, 2019
Our evolving understanding of the mechanism of quinolones
A Gutierrez, JM Stokes, I Matic
Antibiotics 7 (2), 32, 2018
Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology
S French, JP Côté, JM Stokes, R Truant, ED Brown
MBio 8 (2), 10.1128/mbio. 01977-16, 2017
Antibiotic discovery in the artificial intelligence era
T Lluka, JM Stokes
Annals of the New York Academy of Sciences 1519 (1), 74-93, 2023
Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance. Nat Microbiol 2: 17028
JM Stokes, CR MacNair, B Ilyas, S French, JP Côté, C Bouwman, ...
Chemical modulators of ribosome biogenesis as biological probes
JM Stokes, ED Brown
Nature Chemical Biology 11 (12), 924-932, 2015
Discovery of a structural class of antibiotics with explainable deep learning
F Wong, EJ Zheng, JA Valeri, NM Donghia, MN Anahtar, S Omori, A Li, ...
Nature 626 (7997), 177-185, 2024
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