Gautham Vivek Sridharan
Gautham Vivek Sridharan
Principal Scientist, Alnylam Pharmaceuticals
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Gut microbiota-derived tryptophan metabolites modulate inflammatory response in hepatocytes and macrophages
S Krishnan, Y Ding, N Saedi, M Choi, GV Sridharan, DH Sherr, ...
Cell reports 23 (4), 1099-1111, 2018
Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities
UH Jin, SO Lee, G Sridharan, K Lee, LA Davidson, A Jayaraman, ...
Molecular pharmacology 85 (5), 777-788, 2014
Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation
KP Quinn, GV Sridharan, RS Hayden, DL Kaplan, K Lee, I Georgakoudi
Scientific reports 3 (1), 1-10, 2013
Prediction and quantification of bioactive microbiota metabolites in the mouse gut
GV Sridharan, K Choi, C Klemashevich, C Wu, D Prabakaran, LB Pan, ...
Nature communications 5 (1), 1-13, 2014
Endogenous two-photon fluorescence imaging elucidates metabolic changes related to enhanced glycolysis and glutamine consumption in precancerous epithelial tissues
A Varone, J Xylas, KP Quinn, D Pouli, G Sridharan, ...
Cancer research 74 (11), 3067-3075, 2014
Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation
JE Marturano, JF Xylas, GV Sridharan, I Georgakoudi, CK Kuo
Acta biomaterialia 10 (3), 1370-1379, 2014
Metabolic profiling during ex vivo machine perfusion of the human liver
BG Bruinsma, GV Sridharan, PD Weeder, JH Avruch, N Saeidi, S Özer, ...
Scientific reports 6 (1), 1-13, 2016
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation
J Luther, S Khan, MK Gala, D Kedrin, G Sridharan, RP Goodman, ...
Proceedings of the National Academy of Sciences 117 (21), 11667-11673, 2020
Functional human liver preservation and recovery by means of subnormothermic machine perfusion
BG Bruinsma, JH Avruch, PD Weeder, GV Sridharan, BE Uygun, ...
JoVE (Journal of Visualized Experiments), e52777, 2015
Peritransplant energy changes and their correlation to outcome after human liver transplantation
BG Bruinsma, JH Avruch, GV Sridharan, PD Weeder, ML Jacobs, ...
Transplantation 101 (7), 1637, 2017
Neurofilament light chain as a biomarker of hereditary transthyretin-mediated amyloidosis
S Ticau, GV Sridharan, S Tsour, WL Cantley, A Chan, JA Gilbert, D Erbe, ...
Neurology 96 (3), e412-e422, 2021
Identification of biochemical network modules based on shortest retroactive distances
GV Sridharan, S Hassoun, K Lee
PLoS computational biology 7 (11), e1002262, 2011
Analysis of transcription factor network underlying 3T3-L1 adipocyte differentiation
KO Choi, B Ghaddar, C Moya, H Shi, GV Sridharan, K Lee, A Jayaraman
PloS one 9 (7), e100177, 2014
A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity
SS Bale, GV Sridharan, I Golberg, L Prodanov, WJ McCarty, OB Usta, ...
Technology 3 (04), 155-162, 2015
Discovery of substrate cycles in large scale metabolic networks using hierarchical modularity
GV Sridharan, E Ullah, S Hassoun, K Lee
BMC Systems Biology 9 (1), 1-11, 2015
Metabolomic modularity analysis (MMA) to quantify human liver perfusion dynamics
GV Sridharan, BG Bruinsma, SS Bale, A Swaminathan, N Saeidi, ...
Metabolites 7 (4), 58, 2017
Metabolic flux-based modularity using shortest retroactive distances
GV Sridharan, M Yi, S Hassoun, K Lee
BMC systems biology 6 (1), 1-14, 2012
In silico modeling of the impact of antithrombin lowering on thrombin generation in rare bleeding disorders
G Sridharan, J Liu, K Qian, V Goel, S Huang, A Akinc
Blood 130, 3659, 2017
A novel model for ex situ reperfusion of the human liver following subnormothermic machine perfusion
JH Avruch, BG Bruinsma, PD Weeder, GV Sridharan, RJ Porte, H Yeh, ...
Technology 5 (04), 196-200, 2017
Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics
GV Sridharan, M D’Alessandro, SS Bale, V Bhagat, H Gagnon, JM Asara, ...
Technology 5 (03), 139-184, 2017
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