Karen Keeshan
Karen Keeshan
University of Glasgow, School of Cancer Sciences
Verified email at - Homepage
Cited by
Cited by
Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia
K Keeshan, Y He, BJ Wouters, O Shestova, L Xu, H Sai, CG Rodriguez, ...
Cancer cell 10 (5), 401-411, 2006
The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre–T cell receptor
I Maillard, LL Tu, A Sambandam, Y Yashiro-Ohtani, J Millholland, ...
The Journal of experimental medicine 203 (10), 2239-2245, 2006
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
BJ Wouters, MA Jorda, K Keeshan, I Louwers, ...
Blood, The Journal of the American Society of Hematology 110 (10), 3706-3714, 2007
Tribbles in the 21st century: the evolving roles of tribbles pseudokinases in biology and disease
PA Eyers, K Keeshan, N Kannan
Trends in cell biology 27 (4), 284-298, 2017
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression
YX Chen, J Yan, K Keeshan, AT Tubbs, H Wang, A Silva, EJ Brown, ...
Proceedings of the National Academy of Sciences 103 (4), 1018-1023, 2006
Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia
PH Dedhia, K Keeshan, S Uljon, L Xu, ME Vega, O Shestova, ...
Blood, The Journal of the American Society of Hematology 116 (8), 1321-1328, 2010
Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding
K Keeshan, W Bailis, PH Dedhia, ME Vega, O Shestova, L Xu, K Toscano, ...
Blood, The Journal of the American Society of Hematology 116 (23), 4948-4957, 2010
Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis
A Di Bacco, K Keeshan, SL McKenna, TG Cotter
The oncologist 5 (5), 405-415, 2000
Transcription activation function of C/EBPα is required for induction of granulocytic differentiation
K Keeshan, G Santilli, F Corradini, D Perrotti, B Calabretta
Blood 102 (4), 1267-1275, 2003
Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype
K Keeshan, KI Mills, TG Cotter, SL McKenna
Leukemia 15 (12), 1823-1833, 2001
Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation
SM Ryan, GW O’Keeffe, C O’Connor, K Keeshan, YM Nolan
Brain, behavior, and immunity 33, 7-13, 2013
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
DM Foulkes, DP Byrne, W Yeung, S Shrestha, FP Bailey, S Ferries, ...
Science signaling 11 (549), eaat7951, 2018
Targeting the arginine metabolic brake enhances immunotherapy for leukaemia
F Mussai, R Wheat, E Sarrou, S Booth, V Stavrou, L Fultang, T Perry, ...
International journal of cancer 145 (8), 2201-2208, 2019
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias
S Chaudhury, C O’Connor, A Caņete, J Bittencourt-Silvestre, E Sarrou, ...
Nature communications 9 (1), 5280, 2018
Tribbles in acute leukemia
KL Liang, L Rishi, K Keeshan
Blood, The Journal of the American Society of Hematology 121 (21), 4265-4270, 2013
The functionally diverse roles of tribbles
F Lohan, K Keeshan
Biochemical Society Transactions 41 (4), 1096-1100, 2013
Regulation of Trib2 by an E2F1-C/EBPα feedback loop in AML cell proliferation
L Rishi, M Hannon, M Salome, M Hasemann, AK Frank, J Campos, ...
Blood, The Journal of the American Society of Hematology 123 (15), 2389-2400, 2014
Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia
K Keeshan, O Shestova, LS Ussin, WS Pear
Blood Cells, Molecules, and Diseases 40 (1), 119-121, 2008
Pseudokinases: a tribble‐edged sword
L Richmond, K Keeshan
The FEBS Journal 287 (19), 4170-4182, 2020
High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion
K Keeshan, TG Cotter, SL McKenna
Leukemia 16 (9), 1725-1734, 2002
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