| Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy AJ Muller, JB DuHadaway, PS Donover, E Sutanto-Ward, GC Prendergast Nature medicine 11 (3), 312-319, 2005 | 1266 | 2005 |
| Inhibition of indoleamine 2, 3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses DY Hou, AJ Muller, MD Sharma, J DuHadaway, T Banerjee, M Johnson, ... Cancer research 67 (2), 792-801, 2007 | 729 | 2007 |
| Aryl hydrocarbon receptor control of a disease tolerance defence pathway A Bessede, M Gargaro, MT Pallotta, D Matino, G Servillo, C Brunacci, ... Nature 511 (7508), 184-190, 2014 | 708 | 2014 |
| Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2, 3-dioxygenase inhibitory compound D-1-methyl-tryptophan R Metz, JB DuHadaway, U Kamasani, L Laury-Kleintop, AJ Muller, ... Cancer research 67 (15), 7082-7087, 2007 | 613 | 2007 |
| Discovery of IDO1 inhibitors: from bench to bedside GC Prendergast, WP Malachowski, JB DuHadaway, AJ Muller Cancer research 77 (24), 6795-6811, 2017 | 541 | 2017 |
| Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models N Takahashi, L Duprez, S Grootjans, A Cauwels, W Nerinckx, ... Cell death & disease 3 (11), e437-e437, 2012 | 501 | 2012 |
| IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan R Metz, S Rust, JB DuHadaway, MR Mautino, DH Munn, NN Vahanian, ... Oncoimmunology 1 (9), 1460-1468, 2012 | 417 | 2012 |
| IDO is a nodal pathogenic driver of lung cancer and metastasis development C Smith, MY Chang, KH Parker, DW Beury, JB DuHadaway, HE Flick, ... Cancer discovery 2 (8), 722-735, 2012 | 344 | 2012 |
| Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2, 3 dioxygenase AJ Muller, MD Sharma, PR Chandler, JB DuHadaway, ME Everhart, ... Proceedings of the National Academy of Sciences 105 (44), 17073-17078, 2008 | 290 | 2008 |
| Structure− activity study of brassinin derivatives as indoleamine 2, 3-dioxygenase inhibitors P Gaspari, T Banerjee, WP Malachowski, AJ Muller, GC Prendergast, ... Journal of medicinal chemistry 49 (2), 684-692, 2006 | 230 | 2006 |
| Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma K Ge, J DuHadaway, W Du, M Herlyn, U Rodeck, GC Prendergast Proceedings of the National Academy of Sciences 96 (17), 9689-9694, 1999 | 216 | 1999 |
| Indoleamine 2, 3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors S Kumar, WP Malachowski, JB DuHadaway, JM LaLonde, PJ Carroll, ... Journal of medicinal chemistry 51 (6), 1706-1718, 2008 | 209 | 2008 |
| A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2, 3-dioxygenase T Banerjee, JB Duhadaway, P Gaspari, E Sutanto-Ward, DH Munn, ... Oncogene 27 (20), 2851-2857, 2008 | 206 | 2008 |
| IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation R Metz, C Smith, JB DuHadaway, P Chandler, B Baban, LMF Merlo, ... International immunology 26 (7), 357-367, 2014 | 205 | 2014 |
| Structure based development of phenylimidazole-derived inhibitors of indoleamine 2, 3-dioxygenase S Kumar, D Jaller, B Patel, JM LaLonde, JB DuHadaway, ... Journal of medicinal chemistry 51 (16), 4968-4977, 2008 | 200 | 2008 |
| Structural analysis of the human BIN1 gene: evidence for tissue-specific transcriptional regulation and alternate RNA splicing R Wechsler-Reya, D Sakamuro, J Zhang, J Duhadaway, GC Prendergast Journal of Biological Chemistry 272 (50), 31453-31458, 1997 | 169 | 1997 |
| Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation AJ Muller, JF Baker, JB DuHadaway, K Ge, G Farmer, PS Donover, ... Molecular and cellular biology, 2003 | 153 | 2003 |
| CCR5 governs DNA damage repair and breast cancer stem cell expansion X Jiao, MA Velasco-Velazquez, M Wang, Z Li, H Rui, AR Peck, JE Korkola, ... Cancer research 78 (7), 1657-1671, 2018 | 135 | 2018 |
| Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection S Divanovic, NM Sawtell, A Trompette, JI Warning, A Dias, AM Cooper, ... Journal of Infectious Diseases 205 (1), 152-161, 2012 | 134 | 2012 |
| IDO2 is a critical mediator of autoantibody production and inflammatory pathogenesis in a mouse model of autoimmune arthritis LMF Merlo, E Pigott, JB DuHadaway, S Grabler, R Metz, GC Prendergast, ... The Journal of Immunology 192 (5), 2082-2090, 2014 | 125 | 2014 |
