| Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity AB West, DJ Moore, S Biskup, A Bugayenko, WW Smith, CA Ross, ... Proceedings of the National Academy of Sciences 102 (46), 16842-16847, 2005 | 1376 | 2005 |
| Kinase activity of mutant LRRK2 mediates neuronal toxicity WW Smith, Z Pei, H Jiang, VL Dawson, TM Dawson, CA Ross Nature neuroscience 9 (10), 1231-1233, 2006 | 739 | 2006 |
| Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation KL Lim, KCM Chew, JMM Tan, C Wang, KKK Chung, Y Zhang, Y Tanaka, ... Journal of Neuroscience 25 (8), 2002-2009, 2005 | 628 | 2005 |
| Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration WW Smith, Z Pei, H Jiang, DJ Moore, Y Liang, AB West, VL Dawson, ... Proceedings of the National Academy of Sciences 102 (51), 18676-18681, 2005 | 557 | 2005 |
| Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity WW Smith, H Jiang, Z Pei, Y Tanaka, H Morita, A Sawa, VL Dawson, ... Human molecular genetics 14 (24), 3801-3811, 2005 | 472 | 2005 |
| A Drosophila model for LRRK2-linked parkinsonism Z Liu, X Wang, YI Yu, X Li, T Wang, H Jiang, Q Ren, Y Jiao, A Sawa, ... Proceedings of the National Academy of Sciences 105 (7), 2693-2698, 2008 | 340 | 2008 |
| α-Synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells WW Smith, RL Margolis, X Li, JC Troncoso, MK Lee, VL Dawson, ... Journal of Neuroscience 25 (23), 5544-5552, 2005 | 334 | 2005 |
| M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds Y Wang, W Smith, D Hao, B He, L Kong International immunopharmacology 70, 459-466, 2019 | 260 | 2019 |
| Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake S Gao, KP Kinzig, S Aja, KA Scott, W Keung, S Kelly, K Strynadka, ... Proceedings of the National Academy of Sciences 104 (44), 17358-17363, 2007 | 259 | 2007 |
| Signaling events in amyloid β-peptide-induced neuronal death and insulin-like growth factor I protection W Wei, X Wang, JW Kusiak Journal of Biological Chemistry 277 (20), 17649-17656, 2002 | 230 | 2002 |
| Aβ 17–42 in Alzheimer’s disease activates JNK and caspase‐8 leading to neuronal apoptosis W Wei, DD Norton, X Wang, JW Kusiak Brain 125 (9), 2036-2043, 2002 | 211 | 2002 |
| CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity HS Ko, R Bailey, WW Smith, Z Liu, JH Shin, YI Lee, YJ Zhang, H Jiang, ... Proceedings of the National Academy of Sciences 106 (8), 2897-2902, 2009 | 208 | 2009 |
| Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin H Jiang, MA Poirier, Y Liang, Z Pei, CE Weiskittel, WW Smith, ... Neurobiology of disease 23 (3), 543-551, 2006 | 159 | 2006 |
| Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism Z Liu, Y Yu, X Li, CA Ross, WW Smith Pharmacological Research 63 (5), 439-444, 2011 | 156 | 2011 |
| Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models Z Liu, S Hamamichi, B Dae Lee, D Yang, A Ray, GA Caldwell, ... Human molecular genetics 20 (20), 3933-3942, 2011 | 155 | 2011 |
| Overview of RAW264. 7 for osteoclastogensis study: Phenotype and stimuli L Kong, W Smith, D Hao Journal of cellular and molecular medicine 23 (5), 3077-3087, 2019 | 141 | 2019 |
| Phosphorylation of p66Shc and forkhead proteins mediates Aβ toxicity WW Smith, DD Norton, M Gorospe, H Jiang, S Nemoto, NJ Holbrook, ... The Journal of cell biology 169 (2), 331-339, 2005 | 120 | 2005 |
| Gene–environment interactions in Parkinson's disease CA Ross, WW Smith Parkinsonism & related disorders 13, S309-S315, 2007 | 111 | 2007 |
| Evaluation of efficacy on RANKL induced osteoclast from RAW264. 7 cells C Song, X Yang, Y Lei, Z Zhang, W Smith, J Yan, L Kong Journal of cellular physiology 234 (7), 11969-11975, 2019 | 105 | 2019 |
| Baicalein reduces E46K α‐synuclein aggregation in vitro and protects cells against E46K α‐synuclein toxicity in cell models of familiar Parkinsonism M Jiang, Y Porat‐Shliom, Z Pei, Y Cheng, L Xiang, K Sommers, Q Li, ... Journal of neurochemistry 114 (2), 419-429, 2010 | 93 | 2010 |
