Geoff Horsman
Geoff Horsman
Associate Professor of Chemistry, Wilfrid Laurier University
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Phosphonate biochemistry
GP Horsman, DL Zechel
Chemical reviews 117 (8), 5704-5783, 2017
Focusing mutations into the P. fluorescens esterase binding site increases enantioselectivity more effectively than distant mutations
S Park, KL Morley, GP Horsman, M Holmquist, K Hult, RJ Kazlauskas
Chemistry & biology 12 (1), 45-54, 2005
Mutations in Distant Residues Moderately Increase the Enantioselectivity of Pseudomonas fluorescens Esterase towards Methyl 3Bromo‐2‐methylpropanoate and†…
GP Horsman, AMF Liu, E Henke, UT Bornscheuer, RJ Kazlauskas
Chemistry–A European Journal 9 (9), 1933-1939, 2003
Resistance to acetolactate synthase inhibitors and quinclorac in a biotype of false cleavers (Galium spurium)
LM Hall, KM Stromme, GP Horsman, MD Devine
Weed Science 46 (4), 390-396, 1998
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism
NA Lack, KC Yam, ED Lowe, GP Horsman, RL Owen, E Sim, LD Eltis
Journal of biological chemistry 285 (1), 434-443, 2010
Mapping the substrate selectivity of new hydrolases using colorimetric screening: lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas†…
AMF Liu, NA Somers, RJ Kazlauskas, TS Brush, F Zocher, ...
Tetrahedron: Asymmetry 12 (4), 545-556, 2001
Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans
L Liu, T Hao, Z Xie, GP Horsman, Y Chen
Scientific Reports 6 (1), 37479, 2016
Polyketide synthase chemistry does not direct biosynthetic divergence between 9-and 10-membered enediynes
GP Horsman, Y Chen, JS Thorson, B Shen
Proceedings of the National Academy of Sciences 107 (25), 11331-11335, 2010
Phloem Transport of d,l-Glufosinate and Acetyl-l-Glufosinate in Glufosinate-Resistant and -Susceptible Brassica napus
JN Beriault, GP Horsman, MD Devine
Plant Physiology 121 (2), 619-628, 1999
Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
Y Yan, J Yang, Z Yu, M Yu, YT Ma, L Wang, C Su, J Luo, GP Horsman, ...
Nature Communications 7 (1), 13083, 2016
An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters
T Hao, Z Xie, M Wang, L Liu, Y Zhang, W Wang, Z Zhang, X Zhao, P Li, ...
Nature Communications 10 (1), 3665, 2019
Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces
Y Yan, YT Ma, J Yang, GP Horsman, D Luo, X Ji, SX Huang
Organic letters 18 (6), 1254-1257, 2016
Kinetic and Structural Insight into the Mechanism of BphD, a C− C Bond Hydrolase from the Biphenyl Degradation Pathway
GP Horsman, J Ke, S Dai, SYK Seah, JT Bolin, LD Eltis
Biochemistry 45 (37), 11071-11086, 2006
Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation in Streptomyces globisporus
Y Chen, M Yin, GP Horsman, B Shen
Journal of natural products 74 (3), 420-424, 2011
A Glutathione S-Transferase Catalyzes the Dehalogenation of Inhibitory Metabolites of Polychlorinated Biphenyls
PD Fortin, GP Horsman, HM Yang, LD Eltis
Journal of bacteriology 188 (12), 4424-4430, 2006
Characterization of a C—C Bond Hydrolase from Sphingomonas wittichii RW1 with Novel Specificities towards Polychlorinated Biphenyl Metabolites
SYK Seah, J Ke, G Denis, GP Horsman, PD Fortin, CJ Whiting, LD Eltis
Journal of bacteriology 189 (11), 4038-4045, 2007
Spectroscopic studies of the anaerobic enzyme− substrate complex of catechol 1, 2-dioxygenase
GP Horsman, A Jirasek, FH Vaillancourt, CJ Barbosa, AA Jarzecki, C Xu, ...
Journal of the American Chemical Society 127 (48), 16882-16891, 2005
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of†…
JR Lohman, SX Huang, GP Horsman, PE Dilfer, T Huang, Y Chen, ...
Molecular BioSystems 9 (3), 478-491, 2013
The tautomeric half-reaction of BphD, a CC bond hydrolase: kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad
GP Horsman, S Bhowmik, SYK Seah, P Kumar, JT Bolin, LD Eltis
Journal of Biological Chemistry 282 (27), 19894-19904, 2007
Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
Y Chen, M Yin, GP Horsman, S Huang, B Shen
The Journal of antibiotics 63 (8), 482-485, 2010
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