Derek Mann
Derek Mann
Professor of Hepatology, Newcastle University
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Cellular senescence drives age-dependent hepatic steatosis
M Ogrodnik, S Miwa, T Tchkonia, D Tiniakos, CL Wilson, A Lahat, CP Day, ...
Nature communications 8 (1), 15691, 2017
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
D Jurk, C Wilson, JF Passos, F Oakley, C Correia-Melo, L Greaves, ...
Nature communications 5 (1), 4172, 2014
Mitochondria are required for pro‐ageing features of the senescent phenotype
C Correia‐Melo, FDM Marques, R Anderson, G Hewitt, R Hewitt, J Cole, ...
The EMBO journal 35 (7), 724-742, 2016
The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
AM Elsharkawy, F Oakley, DA Mann
Apoptosis 10, 927-939, 2005
Clinical evidence for the regression of liver fibrosis
EL Ellis, DA Mann
Journal of hepatology 56 (5), 1171-1180, 2012
Nuclear factor‐κB and the hepatic inflammation‐fibrosis‐cancer axis
AM Elsharkawy, DA Mann
Hepatology 46 (2), 590-597, 2007
Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
MC Wright, R Issa, DE Smart, N Trim, GI Murray, JN Primrose, MJP Arthur, ...
Gastroenterology 121 (3), 685-698, 2001
MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis
J Mann, DCK Chu, A Maxwell, F Oakley, NL Zhu, H Tsukamoto, DA Mann
Gastroenterology 138 (2), 705-714. e4, 2010
Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
F Oakley, M Meso, JP Iredale, K Green, CJ Marek, X Zhou, MJ May, ...
Gastroenterology 128 (1), 108-120, 2005
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
M Malehmir, D Pfister, S Gallage, M Szydlowska, D Inverso, E Kotsiliti, ...
Nature medicine 25 (4), 641-655, 2019
Multigenerational epigenetic adaptation of the hepatic wound-healing response
M Zeybel, T Hardy, YK Wong, JC Mathers, CR Fox, A Gackowska, ...
Nature medicine 18 (9), 1369-1377, 2012
Transcriptional regulation of hepatic stellate cell activation
DA Mann, DE Smart
Gut 50 (6), 891-896, 2002
Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis
J Mann, F Oakley, F Akiboye, A Elsharkawy, AW Thorne, DA Mann
Cell Death & Differentiation 14 (2), 275-285, 2007
A molecular rheostat: Co-operative rev binding to stem I of the Rev-response element modulates human immunodeficiency virus type-1 late gene expression
DA Mann, I Mikaélian, RW Zemmel, SM Green, AD Lowe, T Kimura, ...
Journal of molecular biology 241 (2), 193-207, 1994
A role for serotonin (5-HT) in hepatic stellate cell function and liver fibrosis
RG Ruddell, F Oakley, Z Hussain, I Yeung, LJ Bryan-Lluka, GA Ramm, ...
The American journal of pathology 169 (3), 861-876, 2006
Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMs
P Doherty, LH Rowett, SE Moore, DA Mann, FS Walsh
Neuron 6 (2), 247-258, 1991
Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease
MR Ebrahimkhani, F Oakley, LB Murphy, J Mann, A Moles, MJ Perugorria, ...
Nature medicine 17 (12), 1668-1673, 2011
Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease
T Hardy, M Zeybel, CP Day, C Dipper, S Masson, S McPherson, ...
Gut 66 (7), 1321-1328, 2017
Signal transduction via the NF‐κB pathway: a targeted treatment modality for infection, inflammation and repair
S Ali, DA Mann
Cell Biochemistry and Function: Cellular biochemistry and its modulation by …, 2004
Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis
MJP Arthur, DA Mann, JP Iredale
Journal of gastroenterology and hepatology 13 (S1), S33-S38, 1998
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